| Active Players |
| 47 | Abanikanda, Israel | RB | 10/05/2002 | 22 | 5' 10" | 216 | Pittsburgh | NYJ | 23 05 143 | 2 |
| 17 | Allen, Brandon | QB | 09/05/1992 | 32 | 6' 01" | 209 | Arkansas | JAX | 16 06 201 | 8 |
| 69 | Anderson, Evan | DT | 02/14/2002 | 22 | 6' 01" | 326 | Florida Atlantic | SF FA | 24 CFA | R |
| 65 | Banks, Aaron | OG | 09/03/1997 | 27 | 6' 05" | 325 | Notre Dame | SF | 21 02 048 | 4 |
| 51 | Beal Jr., Robert | DE | 08/18/1999 | 25 | 6' 04" | 250 | Georgia | SF | 23 05 173 | 2 |
| 97 | Bosa, Nick | DE | 10/23/1997 | 27 | 6' 04" | 266 | Ohio State | SF | 19 01 002 | 6 |
| 64 | Brendel, Jake | OC | 09/10/1992 | 32 | 6' 04" | 299 | UCLA | DAL FA | 16 CFA | 8 |
| 27 | Brown, Ji'Ayir | S | 01/25/2000 | 24 | 5' 11" | 202 | Penn State | SF | 23 03 087 | 2 |
| 74 | Burford, Spencer | OG | 07/19/2000 | 24 | 6' 04" | 300 | UTSA | SF | 22 04 134 | 3 |
| 99 | Collins, Maliek | DT | 04/08/1995 | 29 | 6' 02" | 310 | Nebraska | DAL | 16 03 067 | 9 |
| 18 | Conley, Chris | WR | 10/25/1992 | 32 | 6' 02" | 205 | Georgia | KC | 15 03 076 | 10 |
| 19 | Cowing, Jacob | WR | 02/04/2001 | 23 | 5' 08" | 171 | Arizona | SF | 24 04 135 | R |
| 93 | Davis, Kalia | DT | 10/02/1998 | 26 | 6' 01" | 310 | Central Florida | SF | 22 06 220 | 3 |
| 50 | Davis, Khalil | DT | 08/22/1996 | 28 | 6' 01" | 315 | Nebraska | TB | 20 06 194 | 4 |
| 5 | Dobbs, Joshua | QB | 01/26/1995 | 29 | 6' 03" | 220 | Tennessee | PIT | 17 04 135 | 8 |
| 92 | Elliott, Jordan | DT | 11/23/1997 | 27 | 6' 04" | 303 | Missouri | CLE | 20 03 088 | 5 |
| 45 | Flannigan-Fowles, Demetrius | LB | 09/04/1996 | 28 | 6' 02" | 223 | Arizona | SF FA | 19 CFA | 5 |
| 56 | Floyd, Leonard | DE | 09/08/1992 | 32 | 6' 06" | 240 | Georgia | CHI | 16 01 009 | 9 |
| 43 | Gipson Sr., Tashaun | S | 08/07/1990 | 34 | 6' 01" | 212 | Wyoming | CLE FA | 12 CFA | 13 |
| 0 | Green, Renardo | CB | 11/09/2000 | 24 | 6' 00" | 186 | Florida State | SF | 24 02 064 | R |
| 57 | Greenlaw, Dre | LB | 05/25/1997 | 27 | 5' 11" | 230 | Arkansas | SF | 19 05 148 | 6 |
| 94 | Gross-Matos, Yetur | DE | 02/26/1998 | 26 | 6' 05" | 265 | Penn State | CAR | 20 02 038 | 5 |
| 31 | Guerendo, Isaac | RB | 06/28/2000 | 24 | 6' 00" | 221 | Louisville | SF | 24 04 129 | R |
| 60 | Gutierrez, Sebastian | OT | 07/06/1998 | 26 | 6' 05" | 308 | Minot State | DEN FA | 22 CFA | 1 |
| 29 | Hufanga, Talanoa | S | 02/02/1999 | 25 | 6' 01" | 200 | USC | SF | 21 05 180 | 4 |
| 15 | Jennings, Jauan | WR | 07/10/1997 | 27 | 6' 03" | 212 | Tennessee | SF | 20 07 217 | 4 |
| 44 | Juszczyk, Kyle | FB | 04/23/1991 | 33 | 6' 01" | 235 | Harvard | BAL | 13 04 130 | 12 |
| 85 | Kittle, George | TE | 10/09/1993 | 31 | 6' 04" | 250 | Iowa | SF | 17 05 146 | 8 |
| 2 | Lenoir, Deommodore | CB | 10/06/1999 | 25 | 5' 10" | 200 | Oregon | SF | 21 05 172 | 4 |
| 35 | McCloud, Nick | CB | 07/09/1998 | 26 | 6' 01" | 193 | Notre Dame | BUF FA | 21 CFA | 4 |
| 68 | McKivitz, Colton | OT | 08/09/1996 | 28 | 6' 06" | 301 | West Virginia | SF | 20 05 153 | 5 |
| 4 | Moody, Jake | PK | 11/23/1999 | 25 | 6' 01" | 210 | Michigan | SF | 23 03 099 | 2 |
| 76 | Moore, Jaylon | OT | 01/09/1998 | 26 | 6' 04" | 311 | Western Michigan | SF | 21 05 155 | 4 |
| 6 | Mustapha, Malik | S | 06/25/2002 | 22 | 5' 10" | 206 | Wake Forest | SF | 24 04 124 | R |
| 40 | O'Donnell, Pat | PT | 02/22/1991 | 33 | 6' 04" | 220 | Miami | CHI | 14 06 191 | 10 |
| 91 | Okuayinonu, Sam | DE | 05/01/1998 | 26 | 6' 01" | 269 | Maryland | TEN FA | 22 CFA | 2 |
| 14 | Pearsall, Ricky | WR | 09/09/2000 | 24 | 6' 01" | 192 | Florida | SF | 24 01 031 | R |
| 46 | Pepper, Taybor | LS | 05/28/1994 | 30 | 6' 04" | 245 | Michigan State | GB FA | 17 SFA | 7 |
| 77 | Puni, Dominick | OG | 12/24/2000 | 24 | 6' 05" | 313 | Kansas | SF | 24 03 086 | R |
| 13 | Purdy, Brock | QB | 12/27/1999 | 25 | 6' 01" | 220 | Iowa State | SF | 22 07 262 | 3 |
| 1 | Samuel Sr., Deebo | WR | 01/15/1996 | 28 | 5' 11" | 215 | South Carolina | SF | 19 02 036 | 6 |
| 82 | Saubert, Eric | TE | 05/09/1994 | 30 | 6' 05" | 248 | Drake | ATL | 17 05 174 | 7 |
| 32 | Taylor Jr., Patrick | RB | 04/29/1998 | 26 | 6' 01" | 217 | Memphis | GB FA | 20 CFA | 4 |
| 88 | Tonges, Jake | TE | 07/08/1999 | 25 | 6' 04" | 240 | California | CHI FA | 22 CFA | 2 |
| 7 | Ward, Charvarius | CB | 05/16/1996 | 28 | 6' 01" | 196 | Middle Tennessee | DAL FA | 18 CFA | 7 |
| 54 | Warner, Fred | LB | 11/19/1996 | 28 | 6' 03" | 230 | BYU | SF | 18 03 070 | 7 |
| 71 | Williams, Trent | OT | 08/19/1988 | 36 | 6' 05" | 320 | Oklahoma | WAS | 10 01 004 | 15 |
| 9 | Willis, Brayden | TE | 11/11/1999 | 25 | 6' 03" | 240 | Oklahoma | SF | 23 07 247 | 2 |
| 53 | Winters, Dee | LB | 10/17/2000 | 24 | 5' 11" | 227 | TCU | SF | 23 06 216 | 2 |
| 33 | Ya-Sin, Rock | CB | 05/23/1996 | 28 | 6' 00" | 195 | Temple | IND | 19 02 034 | 6 |
| 22 | Yiadom, Isaac | CB | 02/20/1996 | 28 | 6' 01" | 232 | Boston College | DEN | 18 03 099 | 7 |
| 63 | Zakelj, Nick | OG/OC | 06/22/1999 | 25 | 6' 06" | 316 | Fordham | SF | 22 06 187 | 3 |
| Practice Squad |
| 67 | Alarcon, Isaac | OT | 07/27/1998 | 26 | 6' 07" | 320 | Monterrey Tech | DAL FA | 20 SFA | 1 |
| 58 | Barrett, Alex | DE | 03/06/1994 | 30 | 6' 02" | 250 | San Diego State | DET FA | 17 CFA | 2 |
| 10 | Bell, Ronnie | WR | 01/28/2000 | 24 | 6' 00" | 190 | Michigan | SF | 23 07 253 | 2 |
| 84 | Gage, Russell | WR | 01/22/1996 | 28 | 6' 00" | 184 | LSU | ATL | 18 06 194 | 7 |
| 96 | Garvin, Jonathan | DE | 07/28/1999 | 25 | 6' 04" | 257 | Miami | GB | 20 07 242 | 4 |
| 41 | Graham, Jalen | LB | 01/11/2001 | 23 | 6' 02" | 220 | Purdue | SF | 23 07 255 | 2 |
| 26 | Lucas, Chase | CB | 03/04/1997 | 27 | 5' 11" | 184 | Arizona State | DET | 22 07 237 | 3 |
| 38 | Mahoney, Jaylen | S | 11/19/2000 | 24 | 5' 11" | 200 | Vanderbilt | SF FA | 24 CFA | R |
| 4 | Mordecai, Tanner | QB | 11/08/1999 | 25 | 6' 02" | 218 | Wisconsin | SF FA | 24 CFA | R |
| 66 | Nugent, Drake | OC | 02/09/2001 | 23 | 6' 01" | 298 | Michigan | SF FA | 24 CFA | R |
| 83 | Owens, Terique | WR | 09/25/1999 | 25 | 6' 01" | 193 | Missouri State | SF FA | 24 CFA | R |
| 62 | Pleasants, Austen | OT/OG | 08/22/1997 | 27 | 6' 06" | 328 | Ohio | JAX FA | 20 CFA | 1 |
| 75 | Silvera, Nesta Jade | DT | 01/23/2000 | 24 | 6' 01" | 315 | Arizona State | LV | 23 07 231 | 2 |
| 81 | Taylor, Trent | WR | 04/30/1994 | 30 | 5' 08" | 178 | Louisiana Tech | SF | 17 05 177 | 7 |
| 49 | Vaughn, Ke'Shawn | RB | 05/04/1997 | 27 | 5' 10" | 214 | Vanderbilt | TB | 20 03 076 | 5 |
| 47 | White, DaShaun | LB | 01/02/2000 | 24 | 6' 00" | 218 | Oklahoma | BUF FA | 23 CFA | 1 |
| 59 | Wooten, Chandler | LB | 04/25/1999 | 25 | 6' 03" | 230 | Auburn | ARZ FA | 22 CFA | 3 |
| Reserves |
| 11 | Aiyuk, Brandon | WR | 03/17/1998 | 26 | 6' 00" | 200 | Arizona State | SF | 20 01 025 | 5 |
| 78 | Bartch, Ben | OG/OC | 07/22/1998 | 26 | 6' 06" | 315 | St. John's (MN) | JAX | 20 04 116 | 5 |
| 48 | Bethune, Tatum | LB | 02/19/2001 | 23 | 5' 11" | 299 | Florida State | SF | 24 07 251 | R |
| 59 | Campbell Sr., De'Vondre | LB | 07/01/1993 | 31 | 6' 04" | 232 | Minnesota | ATL | 16 04 115 | 9 |
| 55 | Feliciano, Jon | OG/OC | 02/10/1992 | 32 | 6' 04" | 325 | Miami | OAK | 15 04 128 | 10 |
| 90 | Givens, Kevin | DT | 03/01/1997 | 27 | 6' 01" | 285 | Penn State | SF FA | 19 CFA | 5 |
| 98 | Hargrave, Javon | DT | 02/07/1993 | 31 | 6' 01" | 305 | South Carolina State | PIT | 16 03 089 | 9 |
| 95 | Jackson, Drake | DE | 04/12/2001 | 23 | 6' 04" | 273 | USC | SF | 22 02 062 | 3 |
| 28 | Luter Jr., Darrell | CB | 04/24/2000 | 24 | 6' 00" | 190 | South Alabama | SF | 23 05 155 | 2 |
| 24 | Mason, Jordan | RB | 05/24/1999 | 25 | 5' 11" | 223 | Georgia Tech | SF FA | 22 CFA | 3 |
| 23 | McCaffrey, Christian | RB | 06/07/1996 | 28 | 5' 11" | 210 | Stanford | CAR | 17 01 008 | 8 |
| 25 | Mitchell, Elijah | RB | 05/02/1998 | 26 | 5' 10" | 200 | Louisiana | SF | 21 06 194 | 4 |
| 30 | Odum, George | S | 11/03/1993 | 31 | 6' 01" | 202 | Central Arkansas | IND FA | 18 CFA | 7 |
| 89 | Pline, Mason | TE | 02/05/2000 | 24 | 6' 06" | 254 | Furman | SF FA | 24 CFA | R |
| 36 | Robinson, Curtis | LB | 06/02/1998 | 26 | 6' 03" | 235 | Stanford | DEN FA | 21 CFA | 3 |
| 3 | Wishnowsky, Mitch | PT | 03/02/1992 | 32 | 6' 02" | 220 | Utah | SF | 19 04 110 | 6 |