| Pos | No | Player 1 | No | Player 2 | No | Player 3 | No | Player 4 | No | Player 5 |
| Offense |
| LWR | 84 |
BOURNE, KENDRICK CC/NE
| 17 |
Watkins, Jordan 25/4
| |
| |
| |
|
| RWR | 1 |
Pearsall, Ricky 24/1
| 5 |
ROBINSON, DEMARCUS U/LAR
| |
| |
| |
|
| SWR | 15 |
Jennings, Jauan 20/7
| 9 |
Moore, Skyy T/KC
| |
| |
| |
|
| LT | 71 |
WILLIAMS, TRENT T/Was
| |
| |
| |
| |
|
| LG | 78 |
Bartch, Ben P/Jax
| 74 |
Burford, Spencer 22/4
| |
| |
| |
|
| C | 64 |
BRENDEL, JAKE SF20
| 61 |
Hennessy, Matt P/Atl
| |
| |
| |
|
| RG | 77 |
Puni, Dominick 24/3
| 75 |
Colby, Connor 25/7
| |
| |
| |
|
| RT | 68 |
McKivitz, Colton 20/5
| 62 |
Pleasants, Austen SF24
| |
| |
| |
|
| TE | 85 |
KITTLE, GEORGE 17/5
| 89 |
Farrell, Luke U/Jax
| 88 |
Tonges, Jake SF23
| |
| |
|
| QB | 13 |
Purdy, Brock 22/7
| 10 |
Jones, Mac U/Jax
| 4 |
Martinez, Adrian SF25
| |
| |
|
| RB | 23 |
McCaffrey, Christian T/Car
| 3 |
Robinson Jr., Brian T/Was
| 31 |
Guerendo, Isaac 24/4
| 29 |
James, Jordan 25/5
| |
|
| FB | 44 |
JUSZCZYK, KYLE U/Bal
| |
| |
| |
| |
|
| Defense |
| LDE | 47 |
Huff, Bryce T/Phi
| 51 |
Beal Jr., Robert 23/5
| 96 |
Ferrell, Clelin SF25
| |
| |
|
| LDT | 95 |
Collins, Alfred 25/2
| 92 |
Elliott, Jordan U/Cle
| 99 |
West, C.J. 25/4
| |
| |
|
| RDT | 93 |
Davis, Kalia 22/6
| 90 |
Givens, Kevin CF19
| 55 |
Valdez, Sebastian CF25
| |
| |
|
| RDE | 91 |
Okuayinonu, Sam SF23
| 56 |
White, Keion T/NE
| |
| |
| |
|
| WLB | 53 |
Winters, Dee 23/6
| 59 |
Robinson, Curtis SF21
| 45 |
Martin, Nick 25/3
| |
| |
|
| MLB | 48 |
Bethune, Tatum 24/7
| 57 |
GIFFORD, LUKE U/Ten
| |
| |
| |
|
| LCB | 0 |
Green, Renardo 24/2
| 28 |
Luter Jr., Darrell 23/5
| |
| |
| |
|
| SS | 27 |
Brown, Ji'Ayir 23/3
| 25 |
Pinnock, Jason U/NYG
| |
| |
| |
|
| FS | 6 |
Mustapha, Malik 24/4
| 36 |
Sigle, Marques 25/5
| |
| |
| |
|
| RCB | 2 |
Lenoir, Deommodore 21/5
| 33 |
NEAL, SIRAN U/Mia
| |
| |
| |
|
| NB | 20 |
Stout, Upton 25/3
| 26 |
Lucas, Chase U/Det
| |
| |
| |
|
| Special Teams |
| PT | 7 |
MORSTEAD, THOMAS CC/NYJ
| |
| |
| |
| |
|
| PK | 18 |
PIÑEIRO, EDDY U/Car
| |
| |
| |
| |
|
| LS | 46 |
WEEKS, JON U/Hou
| |
| |
| |
| |
|
| H | 7 |
MORSTEAD, THOMAS CC/NYJ
| |
| |
| |
| |
|
| KO | 18 |
PIÑEIRO, EDDY U/Car
| |
| |
| |
| |
|
| PR | 9 |
Moore, Skyy T/KC
| 17 |
Watkins, Jordan 25/4
| 1 |
Pearsall, Ricky 24/1
| |
| |
|
| KR | 9 |
Moore, Skyy T/KC
| 3 |
Robinson Jr., Brian T/Was
| 31 |
Guerendo, Isaac 24/4
| |
| |
|
| Practice Squad |
| WR | 14 |
Gage Jr., Russell SF24
| 86 |
Bergen, Junior 25/7
| 81 |
Turner, Malik SF24
| |
| |
|
| OT | 67 |
Alarcon, Isaac SF24*
| 60 |
PARKER, BRANDON SF25
| |
| |
| |
|
| OG | 63 |
Zakelj, Nick 22/6
| |
| |
| |
| |
|
| C | 66 |
Nugent, Drake CF24
| |
| |
| |
| |
|
| TE | 82 |
Willis, Brayden 23/7
| |
| |
| |
| |
|
| QB | |
| |
| |
| |
| |
|
| RB | 35 |
McCormick, Sincere SF25
| |
| |
| |
| |
|
| ED | 69 |
Bradley-King, William SF25
| 50 |
Farmer, Andrew SF25
| |
| |
| |
|
| DI | 58 |
Anderson, Evan CF24
| |
| |
| |
| |
|
| LB | 41 |
Graham, Jalen 23/7
| |
| |
| |
| |
|
| CB | 30 |
APPLE, ELI U/LAC
| |
| |
| |
| |
|
| S | 40 |
Canteen, Derrick CF25
| |
| |
| |
| |
|
| Reserves |
| PUP | 11 |
Aiyuk, Brandon WR^
| |
| |
| |
| |
|
| NFI | 4 |
Rourke, Kurtis QB^
| |
| |
| |
| |
|
| IR | 19 |
Cowing, Jacob WR^
| 94 |
Gross-Matos, Yetur DE^
| 54 |
Warner, Fred LB
| 97 |
Bosa, Nick DE
| 81 |
TAYLOR, TRENT WR
|
| IR | 56 |
Jackson, Tarron DE
| 49 |
Robinson, Jakob CB
| 35 |
Tomlinson, Tre CB
| 32 |
Taylor Jr., Patrick RB
| 98 |
Williams, Mykel DE
|