| Active Players |
| 38 | Adams, Tony | S | 01/24/1999 | 27 | 6' 00" | 210 | Illinois | NYJ FA | 22 CFA | 5 |
| 5 | Ayomanor, Elic | WR | 06/15/2003 | 23 | 6' 02" | 206 | Stanford | TEN | 25 04 136 | 2 |
| 50 | Barton, Cody | LB | 11/13/1996 | 29 | 6' 02" | 237 | Utah | SEA | 19 03 088 | 8 |
| 82 | Bellinger, Daniel | TE | 09/22/2000 | 25 | 6' 05" | 255 | San Diego State | NYG | 22 04 112 | 5 |
| 66 | Carmona Jr., Fernando | OG | 07/08/2002 | 24 | 6' 05" | 316 | Arkansas | TEN | 26 05 142 | R |
| 36 | Chestnut, Julius | RB | 10/26/2000 | 25 | 5' 11" | 228 | Sacred Heart | TEN FA | 22 CFA | 5 |
| 79 | Coogan, Pat | C | 11/18/2002 | 23 | 6' 05" | 310 | Indiana | TEN | 26 06 194 | R |
| 46 | Cox, Morgan | LS | 04/26/1986 | 40 | 6' 04" | 233 | Tennessee | BAL FA | 10 CFA | 17 |
| 78 | Crenshaw-Dickson, Brandon | OT | 02/22/2001 | 25 | 6' 07" | 316 | Florida | TEN FA | 25 CFA | 2 |
| 76 | Deculus, Austin | OT | 03/12/1999 | 27 | 6' 05" | 330 | LSU | HOU | 22 06 205 | 4 |
| 71 | Dellinger, Garrett | OG | 02/18/2002 | 24 | 6' 04" | 330 | LSU | BAL | 25 07 243 | 1 |
| 44 | Diabate, Mohamoud | LB | 05/18/2001 | 25 | 6' 03" | 235 | Utah | CLE FA | 23 CFA | 4 |
| 17 | Dike, Chimere | WR | 12/14/2001 | 24 | 6' 01" | 196 | Florida | TEN | 25 04 103 | 2 |
| 95 | Elliott, Jordan | DT | 11/23/1997 | 28 | 6' 04" | 325 | Missouri | CLE | 20 03 088 | 7 |
| 15 | Faulk, Keldric | DE | 09/07/2004 | 21 | 6' 06" | 274 | Auburn | TEN | 26 01 031 | R |
| 18 | Flott, Cor'Dale | CB | 08/24/2001 | 25 | 6' 01" | 175 | LSU | NYG | 22 03 081 | 5 |
| 91 | Franklin-Myers, John | DT | 09/26/1996 | 29 | 6' 04" | 288 | Stephen F. Austin | LAR | 18 04 135 | 9 |
| 86 | Granson, Kylen | TE | 03/27/1998 | 28 | 6' 01" | 242 | SMU | IND | 21 04 127 | 6 |
| 33 | Gray, Cedric | LB | 10/30/2002 | 23 | 6' 01" | 240 | North Carolina | TEN | 24 04 106 | 3 |
| 41 | Hallett II, Erick | S | 04/24/2000 | 26 | 5' 10" | 200 | Pittsburgh | JAX | 23 06 208 | 2 |
| 26 | Harris, Marcus | CB | 03/06/2001 | 25 | 5' 11" | 188 | California | TEN | 25 06 183 | 2 |
| 84 | Helm, Gunnar | TE | 09/06/2002 | 24 | 6' 05" | 241 | Texas | TEN | 25 04 120 | 2 |
| 53 | Hill Jr., Anthony | LB | 02/14/2005 | 21 | 6' 02" | 238 | Texas | TEN | 26 02 060 | R |
| 37 | Hooker, Amani | S | 06/14/1998 | 28 | 5' 11" | 210 | Iowa | TEN | 19 04 116 | 8 |
| 11 | Johnson II, Jermaine | DE | 01/07/1999 | 27 | 6' 05" | 254 | Florida State | NYJ | 22 01 026 | 5 |
| 56 | Jones, Truman | DE | 05/13/2000 | 26 | 6' 03" | 255 | Harvard | KC FA | 23 CFA | 2 |
| 55 | Latham, JC | OT | 02/08/2003 | 23 | 6' 06" | 342 | Alabama | TEN | 24 01 007 | 3 |
| 96 | Marshall, Jackie | DT | 04/26/2003 | 23 | 6' 02" | 293 | Baylor | TEN | 26 06 184 | R |
| 57 | Martin, Jacob | DE | 12/11/1995 | 30 | 6' 02" | 260 | Temple | SEA | 18 06 186 | 9 |
| 88 | Martin-Robinson, David | TE | 12/26/1999 | 26 | 6' 04" | 255 | Temple | TEN FA | 24 CFA | 3 |
| 75 | Moore Jr., Dan | OT | 09/28/1998 | 27 | 6' 05" | 315 | Texas A&M | PIT | 21 04 128 | 6 |
| 7 | Oladejo, Oluwafemi | DE | 09/20/2003 | 22 | 6' 03" | 259 | UCLA | TEN | 25 02 052 | 2 |
| 20 | Pollard, Tony | RB | 04/30/1997 | 29 | 6' 00" | 209 | Memphis | DAL | 19 04 128 | 8 |
| 28 | Reed II, Jerrick | S | 08/07/2000 | 26 | 5' 09" | 197 | New Mexico | SEA | 23 06 198 | 4 |
| 87 | Restrepo, Xavier | WR | 04/22/2002 | 24 | 5' 10" | 202 | Miami | TEN FA | 25 CFA | 1 |
| 0 | Ridley, Calvin | WR | 12/20/1994 | 31 | 6' 00" | 190 | Alabama | ATL | 18 01 026 | 8 |
| 21 | Robinson, Micah | CB | 02/05/2002 | 24 | 5' 11" | 186 | Tulane | GB | 25 07 237 | 2 |
| 4 | Robinson, Wan'Dale | WR | 01/05/2001 | 25 | 5' 08" | 185 | Kentucky | NYG | 22 02 43 | 5 |
| 51 | Schlottmann, Austin | C | 09/18/1995 | 30 | 6' 05" | 310 | TCU | DEN FA | 18 CFA | 8 |
| 98 | Simmons, Jeffery | DT | 07/28/1997 | 29 | 6' 04" | 305 | Mississippi State | TEN | 19 01 019 | 8 |
| 32 | Singleton, Nicholas | RB | 01/06/2004 | 22 | 6' 00" | 219 | Penn State | TEN | 26 05 165 | R |
| 77 | Skoronski, Peter | OG | 07/31/2001 | 25 | 6' 04" | 330 | Northwestern | TEN | 23 01 011 | 4 |
| 64 | Slater, Jackson | OG/C | 05/30/2003 | 23 | 6' 03" | 320 | Sacramento State | TEN | 25 05 167 | 2 |
| 6 | Slye, Joey | PK | 04/10/1996 | 30 | 5' 11" | 228 | Virginia Tech | NYG FA | 19 SFA | 8 |
| 2 | Spears, Tyjae | RB | 06/15/2001 | 25 | 5' 10" | 200 | Tulane | TEN | 23 03 081 | 4 |
| 14 | Tate, Carnell | WR | 01/19/2005 | 21 | 6' 02" | 192 | Ohio State | TEN | 26 01 004 | R |
| 24 | Taylor, Alontae | CB | 12/03/1998 | 27 | 6' 00" | 199 | Tennessee | NO | 22 02 049 | 5 |
| 90 | Thomas, Solomon | DT | 08/26/1995 | 31 | 6' 03" | 285 | Stanford | SF | 17 01 003 | 10 |
| 3 | Townsend, Tommy | PT | 02/14/1995 | 31 | 6' 01" | 191 | Florida | KC FA | 20 CFA | 7 |
| 10 | Trubisky, Mitchell | QB | 08/20/1994 | 32 | 6' 02" | 222 | North Carolina | CHI | 17 01 002 | 10 |
| 1 | Ward, Cam | QB | 05/25/2002 | 24 | 6' 02" | 219 | Miami | TEN | 25 01 001 | 2 |
| 52 | Williams Sr., James | LB | 02/15/2003 | 23 | 6' 04" | 232 | Miami | TEN | 24 07 242 | 3 |
| 23 | Winston Jr., Kevin | S | 12/02/2003 | 22 | 6' 01" | 213 | Penn State | TEN | 25 03 082 | 2 |
| Reserves |
| 45 | Eifler, Milo | LB | 02/13/1998 | 28 | 6' 02" | 225 | Illinois | NYJ FA | 21 CFA | 3 |
| 40 | Hampton, Dominique | LB | 07/25/2000 | 26 | 6' 02" | 220 | Washington | WAS | 24 05 161 | 2 |
| 92 | Harrell, Jaylen | DE | 05/01/2002 | 24 | 6' 04" | 255 | Michigan | TEN | 24 07 252 | 3 |
| 61 | James, Andre | C | 05/02/1997 | 29 | 6' 04" | 300 | UCLA | OAK FA | 19 CFA | 8 |
| 36 | Johnson, Nazeeh | CB | 07/17/1998 | 28 | 5' 10" | 199 | Marshall | KC | 22 07 259 | 5 |
| 81 | Kanak, Jaren | TE | 02/10/2004 | 22 | 6' 02" | 234 | Oklahoma | TEN | 26 07 225 | R |
| 58 | Kpassagnon, Tanoh | DE | 06/14/1994 | 32 | 6' 07" | 289 | Villanova | KC | 17 02 059 | 8 |
| 54 | Mausi, Dorian | LB | 03/05/2002 | 24 | 6' 01" | 234 | Auburn | MIN FA | 25 CFA | 2 |
| 25 | Williams, Joshua | CB | 10/17/1999 | 26 | 6' 03" | 201 | Fayetteville State | KC | 22 04 135 | 5 |