| 1 | Thu, Sep 03 | vs  Akron | W 38-16 | G. Lopez
21/32, 350 yds, 3 TD | T. Clark III
7 car, 105 yds | C. Hernandez
5 rec, 165 yds, 1 TD | Truist Field
Winston-Salem, NC |
| 2 | Sat, Sep 12 | @  Purdue | W 38-36 | G. Lopez
16/27, 225 yds, 1 TD | G. Lopez
14 car, 58 yds, 2 TD | C. Hernandez
6 rec, 88 yds | Ross-Ade Stadium
West Lafayette, IN |
| 3 | Fri, Sep 18 | vs  1 Miami | L 20-33 | G. Lopez
29/46, 312 yds, 3 TD, 1 INT | D. Lawrence
6 car, 27 yds | J. Foley
6 rec, 118 yds, 1 TD | Truist Field
Winston-Salem, NC |
| 4 | Sat, Sep 26 | @  Louisville | W 30-27 | G. Lopez
12/19, 225 yds, 1 TD | T. Clark III
21 car, 91 yds, 2 TD | C. Hernandez
9 rec, 194 yds, 1 TD | Cardinal Stadium
Louisville, KY |
| 5 | Sat, Oct 03 | vs  Stanford | W 57-3 | G. Lopez
20/27, 265 yds, 2 TD | G. Lopez
12 car, 88 yds, 3 TD | C. Hernandez
7 rec, 87 yds | Truist Field
Winston-Salem, NC |
| 7 | Sat, Oct 17 | @  California | W 41-7 | G. Lopez
16/23, 267 yds, 4 TD | J. Searcy
5 car, 61 yds, 1 TD | D. Barry
4 rec, 102 yds, 3 TD | California Memorial Stadium
Berkeley, CA |
| 8 | Sat, Oct 24 | Open Date | | | | |
|
| 9 | Sat, Oct 31 | vs  Virginia | W 51-7 | G. Lopez
13/21, 229 yds, 1 TD | J. Searcy
8 car, 78 yds, 1 TD | C. Hernandez
8 rec, 136 yds, 1 TD | Truist Field
Winston-Salem, NC |
| 10 | Sat, Nov 07 | vs  Merrimack College | | | | | Truist Field
Winston-Salem, NC |
| 11 | Sat, Nov 14 | @  SMU | | | | | Gerald J. Ford Stadium
Dallas, TX |
| 12 | Sat, Nov 21 | @  Georgia Tech | | | | | Bobby Dodd Stadium
Atlanta, GA |
| 13 | Sat, Nov 28 | vs  Duke | | | | | Truist Field
Winston-Salem, NC |
| 14 | Sat, Dec 05 | Open Date | | | | |
|