| 1 | Thu, Sep 03 | vs  Akron | W 38-16 | Truist Field
Winston-Salem, NC |
| 2 | Sat, Sep 12 | @  Purdue | W 38-36 | Ross-Ade Stadium
West Lafayette, IN |
| 3 | Fri, Sep 18 | vs  4 Miami | L 20-33 | Truist Field
Winston-Salem, NC |
| 4 | Sat, Sep 26 | @  Louisville | W 30-27 | Cardinal Stadium
Louisville, KY |
| 5 | Sat, Oct 03 | vs  Stanford | W 57-3 | Truist Field
Winston-Salem, NC |
| 7 | Sat, Oct 17 | @  California | | California Memorial Stadium
Berkeley, CA |
| 8 | Sat, Oct 24 | Open Date | |
|
| 9 | Sat, Oct 31 | vs  Virginia | | Truist Field
Winston-Salem, NC |
| 10 | Sat, Nov 07 | vs Merrimack College | | Truist Field
Winston-Salem, NC |
| 11 | Sat, Nov 14 | @  21 SMU | | Gerald J. Ford Stadium
Dallas, TX |
| 12 | Sat, Nov 21 | @  Georgia Tech | | Bobby Dodd Stadium
Atlanta, GA |
| 13 | Sat, Nov 28 | vs  Duke | | Truist Field
Winston-Salem, NC |
| 14 | Sat, Dec 05 | Open Date | |
|