| 1 | Sat, Sep 05 | Open Date | |
|
| 2 | Fri, Sep 11 | vs Norfolk State | W 59-3 | David A. Harrison III Field at Scott Stadium
Charlottesville, VA |
| 3 | Sat, Sep 19 | vs  West Virginia | L 27-38 | Bank of America Stadium
Charlotte, NC |
| 4 | Sat, Sep 26 | vs  Delaware | W 42-3 | David A. Harrison III Field at Scott Stadium
Charlottesville, VA |
| 5 | Sat, Oct 03 | @  Florida State | L 7-38 | Doak Campbell Stadium
Tallahassee, FL |
| 6 | Sat, Oct 10 | vs  Syracuse | | David A. Harrison III Field at Scott Stadium
Charlottesville, VA |
| 7 | Sat, Oct 17 | @  21 SMU | | Gerald J. Ford Stadium
Dallas, TX |
| 8 | Fri, Oct 23 | vs  Duke | | David A. Harrison III Field at Scott Stadium
Charlottesville, VA |
| 9 | Sat, Oct 31 | @  Wake Forest | | Truist Field
Winston-Salem, NC |
| 10 | Sat, Nov 07 | Open Date | |
|
| 11 | Sat, Nov 14 | vs  California | | David A. Harrison III Field at Scott Stadium
Charlottesville, VA |
| 12 | Sat, Nov 21 | vs  North Carolina | | David A. Harrison III Field at Scott Stadium
Charlottesville, VA |
| 13 | Sat, Nov 28 | @  Virginia Tech | | Lane Stadium/Worsham Field
Blacksburg, VA |
| 14 | Sat, Dec 05 | Open Date | |
|