| 1 | Sat, Sep 05 | vs New Hampshire | W 66-3 | Carrier Dome
Syracuse, NY |
| 2 | Sat, Sep 12 | vs  California | L 18-21 | Carrier Dome
Syracuse, NY |
| 3 | Thu, Sep 17 | @  Pittsburgh | L 13-27 | Acrisure Stadium
Pittsburgh, PA |
| 4 | Sat, Sep 26 | Open Date | |
|
| 5 | Sat, Oct 03 | @  Connecticut | W 42-41 | Pratt & Whitney Stadium at Rentschler Field
Hartford, CT |
| 6 | Sat, Oct 10 | @  Virginia | | David A. Harrison III Field at Scott Stadium
Charlottesville, VA |
| 7 | Sat, Oct 17 | vs  Louisville | | Carrier Dome
Syracuse, NY |
| 8 | Sat, Oct 24 | @  North Carolina | | Kenan Stadium
Chapel Hill, NC |
| 9 | Sat, Oct 31 | vs  21 SMU | | Carrier Dome
Syracuse, NY |
| 10 | Sat, Nov 07 | vs  Clemson | | Carrier Dome
Syracuse, NY |
| 12 | Sat, Nov 21 | @  Boston College | | Alumni Stadium
Chestnut Hill, MA |
| 13 | Sat, Nov 28 | vs  3 Notre Dame | | Carrier Dome
Syracuse, NY |
| 14 | Sat, Dec 05 | Open Date | |
|