| 1 | Sat, Sep 05 | vs  Kent State | W 57-0 | Williams-Brice Stadium
Columbia, SC |
| 2 | Sat, Sep 12 | vs Towson | W 45-9 | Williams-Brice Stadium
Columbia, SC |
| 3 | Sat, Sep 19 | vs  16 Mississippi State | L 34-41 | Williams-Brice Stadium
Columbia, SC |
| 4 | Sat, Sep 26 | @  7 Alabama | L 18-49 | Bryant-Denny Stadium
Tuscaloosa, AL |
| 5 | Sat, Oct 03 | vs  24 Kentucky | L 34-35 | Williams-Brice Stadium
Columbia, SC |
| 6 | Sat, Oct 10 | @  8 Florida | | Ben Hill Griffin Stadium at Florida Field
Gainesville, FL |
| 7 | Sat, Oct 17 | Open Date | |
|
| 8 | Sat, Oct 24 | vs  17 Tennessee | | Williams-Brice Stadium
Columbia, SC |
| 9 | Sat, Oct 31 | @  Oklahoma | | Memorial Stadium at Owen Field
Norman, OK |
| 10 | Sat, Nov 07 | vs  Texas A&M | | Williams-Brice Stadium
Columbia, SC |
| 11 | Sat, Nov 14 | @  Arkansas | | Donald W. Reynolds Razorback Stadium
Fayetteville, AR |
| 12 | Sat, Nov 21 | vs  2 Georgia | | Williams-Brice Stadium
Columbia, SC |
| 13 | Sat, Nov 28 | @  Clemson | | Memorial Stadium
Clemson, SC |
| 14 | Sat, Dec 05 | Open Date | |
|