| 1 | Sat, Sep 05 | vs Houston Christian | W 31-3 | Rice Stadium
Houston, TX |
| 2 | Sat, Sep 12 | @  3 Notre Dame | L 0-52 | Notre Dame Stadium
South Bend, IN |
| 3 | Sat, Sep 19 | vs  Western Michigan | L 21-28 | Rice Stadium
Houston, TX |
| 4 | Sat, Sep 26 | @  Fresno State | L 24-38 | Bulldog Stadium
Fresno, CA |
| 5 | Sat, Oct 03 | vs  UTSA | L 14-16 | Rice Stadium
Houston, TX |
| 6 | Sat, Oct 10 | @  East Carolina | | Dowdy-Ficklen Stadium
Greenville, NC |
| 7 | Sat, Oct 17 | vs  Tulsa | | Rice Stadium
Houston, TX |
| 8 | Sat, Oct 24 | @  Florida Atlantic | | FAU Stadium
Boca Raton, FL |
| 9 | Sat, Oct 31 | Open Date | |
|
| 10 | Sat, Nov 07 | @  North Texas | | Apogee Stadium
Denton, TX |
| 11 | Sat, Nov 14 | vs  Tulane | | Rice Stadium
Houston, TX |
| 12 | Thu, Nov 19 | @  Temple | | Lincoln Financial Field
Philadelphia, PA |
| 13 | Sat, Nov 28 | vs  Army | | Rice Stadium
Houston, TX |
| 14 | Sat, Dec 05 | Open Date | |
|