| 1 | Sat, Sep 05 | vs  Houston Christian | W 31-3 | J. Brown
3/6, 18 yds, 1 TD | T. Byars
16 car, 104 yds | Q. Jackson
2 rec, 13 yds, 1 TD | Rice Stadium
Houston, TX |
| 2 | Sat, Sep 12 | @  4 Notre Dame | L 0-52 | J. Brown
8/12, 64 yds | J. Brown
16 car, 32 yds | B. Jackson Jr.
1 rec, 30 yds | Notre Dame Stadium
South Bend, IN |
| 3 | Sat, Sep 19 | vs  Western Michigan | L 21-28 | J. Brown
11/18, 121 yds, 1 TD | J. Brown
23 car, 128 yds, 1 TD | B. Jackson Jr.
4 rec, 47 yds, 1 TD | Rice Stadium
Houston, TX |
| 4 | Sat, Sep 26 | @  Fresno State | L 24-38 | J. Brown
8/17, 119 yds, 1 TD, 1 INT | J. Brown
19 car, 141 yds, 1 TD | M. Mosey
1 rec, 40 yds, 1 TD | Bulldog Stadium
Fresno, CA |
| 5 | Sat, Oct 03 | vs  UTSA | L 14-16 | J. Brown
6/14, 88 yds | J. Brown
17 car, 96 yds, 2 TD | B. Grice
1 rec, 40 yds | Rice Stadium
Houston, TX |
| 6 | Sat, Oct 10 | @  East Carolina | L 12-28 | G. Ochoa
2/4, 48 yds | T. Byars
14 car, 111 yds, 1 TD | J. Clark
4 rec, 69 yds | Dowdy-Ficklen Stadium
Greenville, NC |
| 7 | Sat, Oct 17 | vs  Tulsa | L 17-38 | J. Brown
2/6, 47 yds | J. Brown
11 car, 155 yds, 2 TD | J. Clark
3 rec, 52 yds | Rice Stadium
Houston, TX |
| 8 | Sat, Oct 24 | @  Florida Atlantic | L 49-51 | G. Ochoa
2/5, 80 yds, 1 TD | G. Ochoa
12 car, 259 yds, 4 TD | B. Walker
1 rec, 71 yds, 1 TD | FAU Stadium
Boca Raton, FL |
| 9 | Sat, Oct 31 | Open Date | | | | |
|
| 10 | Sat, Nov 07 | @  North Texas | | | | | Apogee Stadium
Denton, TX |
| 11 | Sat, Nov 14 | vs  Tulane | | | | | Rice Stadium
Houston, TX |
| 12 | Thu, Nov 19 | @  Temple | | | | | Lincoln Financial Field
Philadelphia, PA |
| 13 | Sat, Nov 28 | vs  Army | | | | | Rice Stadium
Houston, TX |
| 14 | Sat, Dec 05 | Open Date | | | | |
|