| 2 | Sat, Sep 12 | vs  Central Florida | W 12-7 | Acrisure Stadium
Pittsburgh, PA |
| 3 | Thu, Sep 17 | vs  Syracuse | W 27-13 | Acrisure Stadium
Pittsburgh, PA |
| 4 | Sat, Sep 26 | vs Bucknell | W 59-0 | Acrisure Stadium
Pittsburgh, PA |
| 5 | Fri, Oct 02 | @  Virginia Tech | W 35-33 | Lane Stadium/Worsham Field
Blacksburg, VA |
| 6 | Sat, Oct 10 | vs  North Carolina | | Acrisure Stadium
Pittsburgh, PA |
| 7 | Sat, Oct 17 | @  Boston College | | Alumni Stadium
Chestnut Hill, MA |
| 8 | Sat, Oct 24 | @  4 Miami | | Hard Rock Stadium
Miami, FL |
| 9 | Sat, Oct 31 | vs  Georgia Tech | | Acrisure Stadium
Pittsburgh, PA |
| 10 | Sat, Nov 07 | Open Date | |
|
| 11 | Fri, Nov 13 | vs  Florida State | | Acrisure Stadium
Pittsburgh, PA |
| 12 | Sat, Nov 21 | @  Louisville | | Cardinal Stadium
Louisville, KY |
| 13 | Sat, Nov 28 | @  California | | California Memorial Stadium
Berkeley, CA |
| 14 | Sat, Dec 05 | Open Date | |
|