| 2 | Sat, Sep 12 | vs  Central Florida | W 12-7 | M. Heintschel
18/29, 212 yds | D. Ferguson Jr.
20 car, 59 yds, 1 TD | C. Hicks
3 rec, 64 yds | Acrisure Stadium
Pittsburgh, PA |
| 3 | Thu, Sep 17 | vs  Syracuse | W 27-13 | M. Heintschel
10/23, 123 yds, 1 INT | D. Ferguson Jr.
10 car, 102 yds, 1 TD | C. Kent
2 rec, 63 yds | Acrisure Stadium
Pittsburgh, PA |
| 4 | Sat, Sep 26 | vs  Bucknell | W 59-0 | M. Heintschel
29/37, 403 yds, 6 TD | D. Ferguson Jr.
9 car, 56 yds | T. Robinson
5 rec, 78 yds, 1 TD | Acrisure Stadium
Pittsburgh, PA |
| 5 | Fri, Oct 02 | @  Virginia Tech | W 35-33 | M. Heintschel
10/18, 113 yds, 1 TD | J. Turner
14 car, 65 yds, 1 TD | C. Hicks
3 rec, 63 yds, 2 TD | Lane Stadium/Worsham Field
Blacksburg, VA |
| 6 | Sat, Oct 10 | vs  North Carolina | L 17-21 | H. Geriner
27/44, 219 yds, 2 INT | D. Ferguson Jr.
15 car, 49 yds | M. Knight
3 rec, 62 yds | Acrisure Stadium
Pittsburgh, PA |
| 7 | Sat, Oct 17 | @  Boston College | L 21-27 | C. Dailey
11/25, 193 yds, 1 TD, 2 INT | D. Ferguson Jr.
17 car, 119 yds | C. Hicks
5 rec, 135 yds, 1 TD | Alumni Stadium
Chestnut Hill, MA |
| 8 | Sat, Oct 24 | @  1 Miami | L 23-52 | H. Geriner
18/32, 268 yds, 1 TD | D. Ferguson Jr.
9 car, 39 yds, 1 TD | C. Hicks
5 rec, 149 yds, 1 TD | Hard Rock Stadium
Miami, FL |
| 9 | Sat, Oct 31 | vs  Georgia Tech | W 34-11 | H. Geriner
13/30, 180 yds, 1 TD | D. Ferguson Jr.
31 car, 185 yds, 2 TD | C. Lee
3 rec, 56 yds | Acrisure Stadium
Pittsburgh, PA |
| 10 | Sat, Nov 07 | Open Date | | | | |
|
| 11 | Fri, Nov 13 | vs  Florida State | | | | | Acrisure Stadium
Pittsburgh, PA |
| 12 | Sat, Nov 21 | @  Louisville | | | | | Cardinal Stadium
Louisville, KY |
| 13 | Sat, Nov 28 | @  California | | | | | California Memorial Stadium
Berkeley, CA |
| 14 | Sat, Dec 05 | Open Date | | | | |
|