| 1 | Sat, Sep 05 | vs  Marshall | W 45-0 | Beaver Stadium
University Park, PA |
| 2 | Sat, Sep 12 | @  Temple | W 27-9 | Lincoln Financial Field
Philadelphia, PA |
| 3 | Sat, Sep 19 | vs  Buffalo | W 55-13 | Beaver Stadium
University Park, PA |
| 4 | Sat, Sep 26 | vs  Wisconsin | L 20-24 | Beaver Stadium
University Park, PA |
| 5 | Fri, Oct 02 | @  Northwestern | L 13-34 | Ryan Field
Evanston, IL |
| 6 | Sat, Oct 10 | vs  18 USC | | Beaver Stadium
University Park, PA |
| 7 | Sat, Oct 17 | @  Michigan | | Michigan Stadium
Ann Arbor, MI |
| 8 | Sat, Oct 24 | Open Date | |
|
| 9 | Sat, Oct 31 | vs  Purdue | | Beaver Stadium
University Park, PA |
| 10 | Sat, Nov 07 | @  Washington | | Alaska Airlines Field at Husky Stadium
Seattle, WA |
| 11 | Sat, Nov 14 | vs  Minnesota | | Beaver Stadium
University Park, PA |
| 12 | Sat, Nov 21 | vs  Rutgers | | Beaver Stadium
University Park, PA |
| 13 | Sat, Nov 28 | @  Maryland | | Capital One Field at Maryland Stadium
College Park, MD |
| 14 | Sat, Dec 05 | Open Date | |
|