| 1 | Sat, Sep 05 | vs  Ball State | W 56-3 | Ohio Stadium
Columbus, OH |
| 2 | Sat, Sep 12 | @  1 Texas | L 23-24 | Darrell K Royal-Texas Memorial Stadium
Austin, TX |
| 3 | Sat, Sep 19 | vs  Kent State | W 59-3 | Ohio Stadium
Columbus, OH |
| 4 | Sat, Sep 26 | vs  Illinois | W 42-19 | Ohio Stadium
Columbus, OH |
| 5 | Sat, Oct 03 | @  14 Iowa | W 31-14 | Kinnick Stadium
Iowa City, IA |
| 6 | Sat, Oct 10 | vs  Maryland | | Ohio Stadium
Columbus, OH |
| 7 | Sat, Oct 17 | @  6 Indiana | | Memorial Stadium
Bloomington, IN |
| 8 | Sat, Oct 24 | Open Date | |
|
| 9 | Sat, Oct 31 | @  18 USC | | Los Angeles Memorial Coliseum
Los Angeles, CA |
| 10 | Sat, Nov 07 | vs  15 Oregon | | Ohio Stadium
Columbus, OH |
| 11 | Sat, Nov 14 | vs  Northwestern | | Ohio Stadium
Columbus, OH |
| 12 | Sat, Nov 21 | @  Nebraska | | Memorial Stadium
Lincoln, NE |
| 13 | Sat, Nov 28 | vs  Michigan | | Ohio Stadium
Columbus, OH |
| 14 | Sat, Dec 05 | Open Date | |
|