| 1 | Sun, Sep 06 | vs Wisconsin | W 41-13 | C. Carr 19/29, 239 yds, 2 TD | A. Williams 20 car, 90 yds, 2 TD | J. Faison 4 rec, 81 yds | Lambeau Field Green Bay, WI |
| 2 | Sat, Sep 12 | vs Rice | W 52-0 | C. Carr 16/20, 253 yds, 4 TD | J. Walton 8 car, 48 yds | J. Bettis, Jr. 2 rec, 61 yds | Notre Dame Stadium South Bend, IN |
| 3 | Sat, Sep 19 | vs Michigan State | W 27-10 | C. Carr 18/24, 234 yds | N. James, Jr. 26 car, 121 yds, 1 TD | M. Gilbert 8 rec, 170 yds | Notre Dame Stadium South Bend, IN |
| 4 | Sat, Sep 26 | @ Purdue | W 49-10 | C. Carr 14/22, 237 yds, 3 TD, 1 INT | A. Williams 14 car, 80 yds, 1 TD | M. Gilbert 2 rec, 83 yds, 1 TD | Ross-Ade Stadium West Lafayette, IN |
| 5 | Sat, Oct 03 | @ North Carolina | W 37-26 | C. Carr 21/29, 234 yds, 4 TD | J. Walton 23 car, 120 yds | J. Faison 8 rec, 132 yds, 2 TD | Kenan Stadium Chapel Hill, NC |
| 6 | Sat, Oct 10 | vs Stanford | W 58-7 | C. Carr 14/20, 181 yds, 3 TD | J. Walton 13 car, 181 yds, 2 TD | A. Williams 1 rec, 70 yds, 1 TD | Notre Dame Stadium South Bend, IN |
| 7 | Sat, Oct 17 | @ 7 BYU | L 24-28 | C. Carr 27/49, 261 yds | N. James, Jr. 16 car, 77 yds, 1 TD | J. Greathouse 8 rec, 125 yds | LaVell Edwards Stadium Provo, UT |
| 8 | Sat, Oct 24 | Open Date | | | | | |
| 9 | Sat, Oct 31 | vs Navy | W 35-13 | C. Carr 19/29, 210 yds, 2 TD | N. James, Jr. 9 car, 107 yds, 2 TD | J. Bettis, Jr. 6 rec, 78 yds, 1 TD | Gillette Stadium Foxboro, MA |
| 10 | Sat, Nov 07 | vs 1 Miami | | | | | Notre Dame Stadium South Bend, IN |
| 11 | Sat, Nov 14 | vs Boston College | | | | | Notre Dame Stadium South Bend, IN |
| 12 | Sat, Nov 21 | vs SMU | | | | | Notre Dame Stadium South Bend, IN |
| 13 | Sat, Nov 28 | @ Syracuse | | | | | Carrier Dome Syracuse, NY |