| 1 | Sat, Sep 05 | vs Western Michigan | W 13-12 | B. Underwood 12/22, 170 yds, 1 TD, 1 INT | B. Underwood 9 car, 47 yds, 1 TD | J. Buchanan 6 rec, 126 yds, 1 TD | Michigan Stadium Ann Arbor, MI |
| 2 | Sat, Sep 12 | vs Oklahoma | W 17-10 | B. Underwood 9/17, 111 yds | B. Underwood 18 car, 87 yds, 1 TD | J. Buchanan 2 rec, 48 yds | Michigan Stadium Ann Arbor, MI |
| 3 | Sat, Sep 19 | vs UTEP | W 52-17 | B. Underwood 19/25, 223 yds, 2 TD | S. Hiter 11 car, 62 yds, 2 TD | A. Marsh 10 rec, 105 yds, 1 TD | Michigan Stadium Ann Arbor, MI |
| 4 | Sat, Sep 26 | vs 21 Iowa | L 19-20 | B. Underwood 17/28, 276 yds, 2 TD, 1 INT | J. Marshall 11 car, 59 yds | J. Buchanan 5 rec, 130 yds, 2 TD | Michigan Stadium Ann Arbor, MI |
| 5 | Sat, Oct 03 | @ Minnesota | L 14-20 | B. Underwood 10/21, 101 yds, 2 INT | J. Marshall 10 car, 50 yds, 1 TD | J. Buchanan 4 rec, 50 yds | TCF Bank Stadium Minneapolis, MN |
| 6 | Sat, Oct 10 | Open Date | | | | | |
| 7 | Sat, Oct 17 | vs Penn State | W 21-18 | T. Carr 5/7, 47 yds | S. Hiter 11 car, 78 yds | J. Buchanan 3 rec, 36 yds | Michigan Stadium Ann Arbor, MI |
| 8 | Sat, Oct 24 | vs 6 Indiana | L 6-13 | T. Carr 20/32, 167 yds, 1 INT | J. Marshall 12 car, 26 yds | J. Buchanan 6 rec, 57 yds | Michigan Stadium Ann Arbor, MI |
| 9 | Sat, Oct 31 | @ Rutgers | W 28-21 | T. Carr 22/27, 266 yds, 1 TD | S. Hiter 20 car, 76 yds | J. Buchanan 5 rec, 63 yds, 1 TD | SHI Stadium Piscataway, NJ |
| 10 | Sat, Nov 07 | vs Michigan State | | | | | Michigan Stadium Ann Arbor, MI |
| 11 | Sat, Nov 14 | @ Oregon | | | | | Autzen Stadium Eugene, OR |
| 12 | Sat, Nov 21 | vs 5 UCLA | | | | | Michigan Stadium Ann Arbor, MI |
| 13 | Sat, Nov 28 | @ 11 Ohio State | | | | | Ohio Stadium Columbus, OH |
| 14 | Sat, Dec 05 | Open Date | | | | | |