| 1 | Fri, Sep 04 | vs Toledo | W 30-20 | A. Milivojevic 26/34, 247 yds, 1 TD | C. Edwards 27 car, 98 yds, 1 TD | R. Bullard Jr. 7 rec, 90 yds, 1 TD | Spartan Stadium East Lansing, MI |
| 2 | Sat, Sep 12 | vs Eastern Michigan | W 35-7 | A. Milivojevic 12/20, 170 yds, 2 TD | C. Edwards 21 car, 152 yds, 2 TD | C. Taplin 3 rec, 65 yds, 1 TD | Spartan Stadium East Lansing, MI |
| 3 | Sat, Sep 19 | @ 4 Notre Dame | L 10-27 | A. Milivojevic 9/17, 123 yds, 2 INT | C. Edwards 12 car, 38 yds | R. Bullard Jr. 2 rec, 66 yds | Notre Dame Stadium South Bend, IN |
| 4 | Sat, Sep 26 | vs Nebraska | L 13-31 | A. Milivojevic 18/26, 208 yds, 1 INT | J. Patterson 16 car, 54 yds, 1 TD | C. McCray 4 rec, 47 yds | Spartan Stadium East Lansing, MI |
| 5 | Sat, Oct 03 | @ Wisconsin | L 3-31 | A. Milivojevic 15/32, 103 yds | J. Patterson 18 car, 62 yds | J. Savoury 4 rec, 26 yds | Camp Randall Stadium Madison, WI |
| 6 | Sat, Oct 10 | vs Illinois | L 37-38 | A. Milivojevic 22/26, 196 yds, 2 TD | J. Patterson 17 car, 93 yds, 3 TD | J. Savoury 6 rec, 49 yds | Spartan Stadium East Lansing, MI |
| 7 | Sat, Oct 17 | vs Northwestern | L 21-24 | A. Milivojevic 19/30, 216 yds, 2 TD | J. Patterson 15 car, 72 yds | C. McCray 3 rec, 64 yds, 1 TD | Spartan Stadium East Lansing, MI |
| 8 | Sat, Oct 24 | @ 5 UCLA | L 10-28 | L. Hannan 9/15, 67 yds, 1 INT | K. Williams 17 car, 54 yds | C. McCray 3 rec, 42 yds | Rose Bowl Pasadena, CA |
| 9 | Sat, Oct 31 | Open Date | | | | | |
| 10 | Sat, Nov 07 | @ Michigan | | | | | Michigan Stadium Ann Arbor, MI |
| 11 | Sat, Nov 14 | vs Washington | | | | | Spartan Stadium East Lansing, MI |
| 12 | Fri, Nov 20 | vs Oregon | | | | | Spartan Stadium East Lansing, MI |
| 13 | Sat, Nov 28 | @ Rutgers | | | | | SHI Stadium Piscataway, NJ |
| 14 | Sat, Dec 05 | Open Date | | | | | |