| 1 | Sat, Sep 05 | @  Pittsburgh | L 14-59 | Acrisure Stadium
Pittsburgh, PA |
| 2 | Sat, Sep 12 | vs Holy Cross | W 45-7 | Fred C. Yager Stadium
Oxford, OH |
| 3 | Sat, Sep 19 | vs  Cincinnati | L 31-35 | TQL Stadium
Cincinnati, OH |
| 4 | Sat, Sep 26 | vs  Connecticut | W 24-21 | Fred C. Yager Stadium
Oxford, OH |
| 5 | Sat, Oct 03 | vs  Bowling Green | L 20-24 | Fred C. Yager Stadium
Oxford, OH |
| 6 | Sat, Oct 10 | @  Massachusetts | | Warren McGuirk Alumni Stadium
Amherst, MA |
| 7 | Sat, Oct 17 | vs  Akron | | Fred C. Yager Stadium
Oxford, OH |
| 8 | Sat, Oct 24 | @  Central Michigan | | Kelly/Shorts Stadium
Mount Pleasant, MI |
| 9 | Sat, Oct 31 | Open Date | |
|
| 10 | Tue, Nov 03 | vs  Buffalo | | Fred C. Yager Stadium
Oxford, OH |
| 11 | Tue, Nov 10 | vs  Ohio | | Fred C. Yager Stadium
Oxford, OH |
| 12 | Tue, Nov 17 | @  Kent State | | Dix Stadium
Kent, OH |
| 13 | Tue, Nov 24 | @  Western Michigan | | Waldo Stadium
Kalamazoo, MI |
| 14 | Sat, Dec 05 | Open Date | |
|