| 1 | Sun, Sep 06 | vs  9 Mississippi | L 38-41 | Nissan Stadium
Nashville, TN |
| 2 | Fri, Sep 11 | vs Villanova | W 59-13 | Cardinal Stadium
Louisville, KY |
| 3 | Sat, Sep 19 | vs  21 SMU | W 41-31 | Cardinal Stadium
Louisville, KY |
| 4 | Sat, Sep 26 | vs  Wake Forest | L 27-30 | Cardinal Stadium
Louisville, KY |
| 6 | Fri, Oct 09 | vs  Florida State | | Cardinal Stadium
Louisville, KY |
| 7 | Sat, Oct 17 | @  Syracuse | | Carrier Dome
Syracuse, NY |
| 8 | Sat, Oct 24 | Open Date | |
|
| 9 | Sat, Oct 31 | vs  Stanford | | Cardinal Stadium
Louisville, KY |
| 10 | Sat, Nov 07 | @  Georgia Tech | | Bobby Dodd Stadium
Atlanta, GA |
| 11 | Sat, Nov 14 | @  North Carolina | | Kenan Stadium
Chapel Hill, NC |
| 12 | Sat, Nov 21 | vs  Pittsburgh | | Cardinal Stadium
Louisville, KY |
| 13 | Sat, Nov 28 | @  24 Kentucky | | Kroger Field
Lexington, KY |
| 14 | Sat, Dec 05 | Open Date | |
|