| 1 | Sat, Sep 05 | vs  Oregon State | W 33-20 | C. Weigman
20/30, 305 yds, 1 TD, 1 INT | M. Hughes
17 car, 98 yds, 1 TD | A. Thomas
8 rec, 133 yds, 1 TD | TDECU Stadium
Houston, TX |
| 2 | Sat, Sep 12 | vs  Southern | W 77-6 | C. Weigman
9/12, 120 yds, 3 TD | Z. Smith
10 car, 69 yds | K. Young
3 rec, 54 yds, 2 TD | TDECU Stadium
Houston, TX |
| 3 | Fri, Sep 18 | @  13 Texas Tech | L 26-28 | C. Weigman
27/38, 283 yds, 3 TD | M. Hughes
15 car, 70 yds | A. Thomas
7 rec, 75 yds, 1 TD | Jones AT&T Stadium
Lubbock, TX |
| 4 | Sat, Sep 26 | @  Georgia Southern | W 42-28 | C. Weigman
17/22, 239 yds, 4 TD | R. Sanford II
17 car, 120 yds | T. Walker
6 rec, 83 yds, 1 TD | Allen E. Paulson Stadium
Statesboro, GA |
| 5 | Sat, Oct 03 | vs  Central Florida | W 27-17 | C. Weigman
18/33, 239 yds | R. Sanford II
18 car, 62 yds | P. Overmyer
6 rec, 76 yds | TDECU Stadium
Houston, TX |
| 6 | Sat, Oct 10 | @  Kansas State | W 35-16 | C. Weigman
19/30, 242 yds, 4 TD | R. Sanford II
20 car, 90 yds | P. Overmyer
8 rec, 83 yds, 4 TD | Bill Snyder Family Stadium
Manhattan, KS |
| 7 | Sat, Oct 17 | vs  Oklahoma State | W 35-32 | C. Weigman
24/33, 343 yds, 5 TD, 1 INT | M. Hughes
18 car, 77 yds | A. Thomas
7 rec, 126 yds, 2 TD | TDECU Stadium
Houston, TX |
| 8 | Sat, Oct 24 | @  3 Utah | L 13-21 | C. Weigman
19/35, 282 yds | M. Hughes
19 car, 52 yds, 1 TD | A. Thomas
5 rec, 133 yds | Rice-Eccles Stadium
Salt Lake City, UT |
| 9 | Sat, Oct 31 | Open Date | | | | |
|
| 10 | Sat, Nov 07 | vs  Cincinnati | | | | | TDECU Stadium
Houston, TX |
| 11 | Fri, Nov 13 | @  Colorado | | | | | Folsom Field
Boulder, CO |
| 12 | Sat, Nov 21 | @  West Virginia | | | | | Mountaineer Field at Milan Puskar Stadium
Morgantown, WV |
| 13 | Sat, Nov 28 | vs  Baylor | | | | | TDECU Stadium
Houston, TX |
| 14 | Fri, Dec 04 | Open Date | | | | |
|