| 1 | Sat, Sep 05 | vs  Oregon State | W 33-20 | TDECU Stadium
Houston, TX |
| 2 | Sat, Sep 12 | vs Southern | W 77-6 | TDECU Stadium
Houston, TX |
| 3 | Fri, Sep 18 | @  12 Texas Tech | L 26-28 | Jones AT&T Stadium
Lubbock, TX |
| 4 | Sat, Sep 26 | @  Georgia Southern | W 42-28 | Allen E. Paulson Stadium
Statesboro, GA |
| 5 | Sat, Oct 03 | vs  Central Florida | W 27-17 | TDECU Stadium
Houston, TX |
| 6 | Sat, Oct 10 | @  Kansas State | | Bill Snyder Family Stadium
Manhattan, KS |
| 7 | Sat, Oct 17 | vs  19 Oklahoma State | | TDECU Stadium
Houston, TX |
| 8 | Sat, Oct 24 | @  13 Utah | | Rice-Eccles Stadium
Salt Lake City, UT |
| 9 | Sat, Oct 31 | Open Date | |
|
| 10 | Sat, Nov 07 | vs  Cincinnati | | TDECU Stadium
Houston, TX |
| 11 | Fri, Nov 13 | @  Colorado | | Folsom Field
Boulder, CO |
| 12 | Sat, Nov 21 | @  West Virginia | | Mountaineer Field at Milan Puskar Stadium
Morgantown, WV |
| 13 | Sat, Nov 28 | vs  Baylor | | TDECU Stadium
Houston, TX |
| 14 | Fri, Dec 04 | Open Date | |
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