| 1 | Sat, Sep 05 | vs  Tulane | W 17-3 | Wallace Wade Stadium
Durham, NC |
| 2 | Sat, Sep 12 | @  Illinois | W 31-27 | Memorial Stadium
Champaign, IL |
| 3 | Sat, Sep 19 | vs  Stanford | W 35-7 | Wallace Wade Stadium
Durham, NC |
| 4 | Sat, Sep 26 | vs William & Mary | W 62-7 | Wallace Wade Stadium
Durham, NC |
| 5 | Sat, Oct 03 | Open Date | |
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| 6 | Sat, Oct 10 | @  Georgia Tech | | Bobby Dodd Stadium
Atlanta, GA |
| 7 | Sat, Oct 17 | vs  North Carolina | | Wallace Wade Stadium
Durham, NC |
| 8 | Fri, Oct 23 | @  Virginia | | David A. Harrison III Field at Scott Stadium
Charlottesville, VA |
| 9 | Sat, Oct 31 | vs  Boston College | | Wallace Wade Stadium
Durham, NC |
| 11 | Sat, Nov 14 | @  4 Miami | | Hard Rock Stadium
Miami, FL |
| 12 | Fri, Nov 20 | vs  Clemson | | Wallace Wade Stadium
Durham, NC |
| 13 | Sat, Nov 28 | @  Wake Forest | | Truist Field
Winston-Salem, NC |
| 14 | Sat, Dec 05 | Open Date | |
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