| 1 | Sat, Sep 05 | vs  Tulane | W 17-3 | W. Eget
13/26, 131 yds | N. Sheppard
35 car, 227 yds, 2 TD | J. Burton
3 rec, 38 yds | Wallace Wade Stadium
Durham, NC |
| 2 | Sat, Sep 12 | @  Illinois | W 31-27 | W. Eget
15/21, 206 yds, 3 TD | N. Sheppard
24 car, 147 yds, 1 TD | J. Burton
4 rec, 76 yds, 1 TD | Memorial Stadium
Champaign, IL |
| 3 | Sat, Sep 19 | vs  Stanford | W 35-7 | W. Eget
14/24, 202 yds, 1 TD, 1 INT | N. Sheppard
23 car, 154 yds, 2 TD | J. Hasley
5 rec, 88 yds | Wallace Wade Stadium
Durham, NC |
| 4 | Sat, Sep 26 | vs  William & Mary | W 62-7 | W. Eget
16/22, 182 yds, 2 TD | N. Sheppard
9 car, 116 yds, 1 TD | J. Burton
5 rec, 63 yds | Wallace Wade Stadium
Durham, NC |
| 5 | Sat, Oct 03 | Open Date | | | | |
|
| 6 | Sat, Oct 10 | @  Georgia Tech | L 25-28 | W. Eget
26/41, 259 yds, 1 TD | N. Sheppard
27 car, 99 yds, 2 TD | N. Sheppard
7 rec, 91 yds | Bobby Dodd Stadium
Atlanta, GA |
| 7 | Sat, Oct 17 | vs  North Carolina | L 20-24 | W. Eget
24/38, 249 yds, 1 TD, 1 INT | N. Sheppard
20 car, 77 yds | N. Sheppard
11 rec, 98 yds, 1 TD | Wallace Wade Stadium
Durham, NC |
| 8 | Fri, Oct 23 | @  Virginia | W 19-16 | W. Eget
14/25, 211 yds, 1 INT | N. Sheppard
15 car, 55 yds, 1 TD | J. Burton
4 rec, 59 yds | David A. Harrison III Field at Scott Stadium
Charlottesville, VA |
| 9 | Sat, Oct 31 | vs  Boston College | W 47-2 | W. Eget
11/18, 201 yds, 1 TD | N. Sheppard
20 car, 97 yds, 5 TD | J. Hasley
3 rec, 55 yds, 1 TD | Wallace Wade Stadium
Durham, NC |
| 11 | Sat, Nov 14 | @  1 Miami | | | | | Hard Rock Stadium
Miami, FL |
| 12 | Fri, Nov 20 | vs  Clemson | | | | | Wallace Wade Stadium
Durham, NC |
| 13 | Sat, Nov 28 | @  14 Wake Forest | | | | | Truist Field
Winston-Salem, NC |
| 14 | Sat, Dec 05 | Open Date | | | | |
|