| 1 | Sat, Sep 05 | vs  Boston College | W 34-15 | Nippert Stadium
Cincinnati, OH |
| 2 | Sat, Sep 12 | vs Western Carolina | W 62-10 | Nippert Stadium
Cincinnati, OH |
| 4 | Sat, Sep 26 | vs  Kansas State | W 31-26 | Nippert Stadium
Cincinnati, OH |
| 5 | Sat, Oct 03 | @  Arizona | L 7-34 | Arizona Stadium
Tucson, AZ |
| 6 | Sat, Oct 10 | Open Date | |
|
| 7 | Sat, Oct 17 | @  West Virginia | | Mountaineer Field at Milan Puskar Stadium
Morgantown, WV |
| 8 | Sat, Oct 24 | vs  12 Texas Tech | | Nippert Stadium
Cincinnati, OH |
| 9 | Sat, Oct 31 | vs  13 Utah | | Nippert Stadium
Cincinnati, OH |
| 10 | Sat, Nov 07 | @  20 Houston | | TDECU Stadium
Houston, TX |
| 11 | Sat, Nov 14 | @  Iowa State | | MidAmerican Energy Field at Jack Trice Stadium
Ames, IA |
| 12 | Sat, Nov 21 | vs  Colorado | | Nippert Stadium
Cincinnati, OH |
| 13 | Sat, Nov 28 | @  10 BYU | | LaVell Edwards Stadium
Provo, UT |
| 14 | Fri, Dec 04 | Open Date | |
|