| 1 | Sat, Sep 05 | vs  Texas-Rio Grande Valley | W 45-16 | O. McCown
22/27, 275 yds, 3 TD | W. Henderson III
9 car, 101 yds, 1 TD | D. Allen, Jr.
3 rec, 116 yds, 1 TD | Alamodome
San Antonio, TX |
| 2 | Sat, Sep 12 | @  Texas State | W 31-26 | O. McCown
28/42, 214 yds, 1 TD | W. Henderson III
14 car, 80 yds | A. Wilson
9 rec, 83 yds | Bobcat Stadium
San Marcos, TX |
| 3 | Sat, Sep 19 | @  10 Texas | L 6-30 | O. McCown
14/23, 70 yds, 1 INT | W. Henderson III
10 car, 38 yds | B. High, Jr.
3 rec, 20 yds | Darrell K Royal-Texas Memorial Stadium
Austin, TX |
| 4 | Sat, Sep 26 | vs  Colorado State | W 59-45 | O. McCown
20/30, 303 yds, 3 TD | W. Henderson III
14 car, 89 yds, 1 TD | D. Allen, Jr.
5 rec, 87 yds, 1 TD | Alamodome
San Antonio, TX |
| 5 | Sat, Oct 03 | @  Rice | W 16-14 | O. McCown
19/29, 148 yds, 1 INT | W. Henderson III
18 car, 90 yds, 1 TD | D. Amador II
7 rec, 48 yds | Rice Stadium
Houston, TX |
| 6 | Thu, Oct 08 | vs  South Florida | W 31-24 | O. McCown
22/31, 209 yds | A. Peterson
12 car, 92 yds, 3 TD | D. Amador II
9 rec, 70 yds | Alamodome
San Antonio, TX |
| 7 | Sat, Oct 17 | vs  Navy | W 38-34 | O. McCown
28/38, 359 yds, 3 TD | W. Henderson III
16 car, 78 yds, 1 TD | D. Amador II
7 rec, 71 yds | Alamodome
San Antonio, TX |
| 8 | Sat, Oct 24 | @  Tulane | W 42-19 | O. McCown
16/23, 173 yds, 2 INT | W. Henderson III
15 car, 102 yds, 1 TD | D. Amador II
5 rec, 47 yds | Yulman Stadium
New Orleans, LA |
| 9 | Sat, Oct 31 | Open Date | | | | |
|
| 10 | Thu, Nov 05 | @  Florida Atlantic | | | | | FAU Stadium
Boca Raton, FL |
| 11 | Sat, Nov 14 | vs  North Texas | | | | | Alamodome
San Antonio, TX |
| 12 | Sat, Nov 21 | @  UAB | | | | | Protective Stadium
Birmingham, AL |
| 13 | Sat, Nov 28 | vs  Tulsa | | | | | Alamodome
San Antonio, TX |
| 14 | Sat, Dec 05 | Open Date | | | | |
|