| 1 | Sat, Sep 05 | @ 15 LSU | L 10-51 | C. Vizzina 10/16, 83 yds, 1 INT | J. Green 4 car, 21 yds | T. Moore 4 rec, 31 yds | Tiger Stadium Baton Rouge, LA |
| 2 | Sat, Sep 12 | vs Georgia Southern | W 22-7 | T. Reynolds 16/27, 178 yds | G. Davidson 14 car, 62 yds | T. Moore 7 rec, 103 yds, 1 TD | Memorial Stadium Clemson, SC |
| 3 | Sat, Sep 19 | vs North Carolina | W 28-20 | T. Reynolds 20/29, 215 yds, 1 TD, 1 INT | G. Davidson 16 car, 105 yds, 1 TD | B. Wesco, Jr. 5 rec, 77 yds | Memorial Stadium Clemson, SC |
| 4 | Fri, Sep 25 | @ California | W 24-10 | T. Reynolds 14/22, 106 yds, 1 INT | G. Davidson 22 car, 159 yds, 2 TD | T. Brown 3 rec, 29 yds | California Memorial Stadium Berkeley, CA |
| 5 | Sat, Oct 03 | vs 1 Miami | L 13-41 | T. Reynolds 29/44, 295 yds, 1 INT | C. Johnson, Jr. 5 car, 32 yds | B. Wesco, Jr. 9 rec, 152 yds | Memorial Stadium Clemson, SC |
| 6 | Sat, Oct 10 | Open Date | | | | | |
| 7 | Sat, Oct 17 | vs Charleston Southern | W 37-0 | T. Reynolds 17/26, 127 yds | G. Davidson 13 car, 59 yds, 1 TD | C. Bentancur 4 rec, 74 yds | Memorial Stadium Clemson, SC |
| 8 | Sat, Oct 24 | vs Virginia Tech | L 16-20 | T. Reynolds 20/26, 153 yds | T. Reynolds 18 car, 63 yds, 1 TD | T. Brown 8 rec, 62 yds | Memorial Stadium Clemson, SC |
| 9 | Sat, Oct 31 | @ Florida State | W 36-24 | T. Reynolds 18/32, 189 yds, 2 TD | T. Reynolds 14 car, 85 yds, 1 TD | T. Brown 5 rec, 74 yds | Doak Campbell Stadium Tallahassee, FL |
| 10 | Sat, Nov 07 | @ Syracuse | | | | | Carrier Dome Syracuse, NY |
| 11 | Sat, Nov 14 | vs Georgia Tech | | | | | Memorial Stadium Clemson, SC |
| 12 | Fri, Nov 20 | @ Duke | | | | | Wallace Wade Stadium Durham, NC |
| 13 | Sat, Nov 28 | vs 23 South Carolina | | | | | Memorial Stadium Clemson, SC |
| 14 | Sat, Dec 05 | Open Date | | | | | |